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Agentic Analytics for Clinical Trials

Beyond Dashboards.Beyond Chatbots.

AI That Reasons and Acts

Zynomi's Agentic Analytics is designed as a crew of bounded agents — not a single chatbot. A supervisor that owns no data tools routes each question to a specialist bound to exactly one engine: the governed semantic layer or the temporal knowledge graph (clinical ontology + GraphRAG), connected through MCP. Every number is traceable back to source data.

Agentic Analytics AI Chatbot Demo

Watch the AI Agent in Action

What is Agentic Analytics?

The Next Evolution in Data Intelligence

The term 'AI' is everywhere, but most tools hit a ceiling: one chatbot, one prompt, one answer. Real data work isn't about single questions — it's about multi-step investigation and reasoning. Zynomi's Agentic Analytics is designed as a crew of bounded specialists routed by a supervisor, each grounded in exactly one engine — so answers reason and act with rich context while staying traceable. Digital teammates, not just tools.

Reason

Deep Context Understanding

A simple chatbot might translate 'show me enrollment' into SQL. But what does 'enrolled' mean? Is it consented? Screened? Active? An agent grounded in the semantic layer knows precisely how metrics are calculated — and an agent grounded in the temporal knowledge graph knows how entities connect and how they evolved over time.

Act

Multi-Step Analysis

The most significant leap from a chatbot to an agent is the ability to act on a goal through a series of steps. Ask for 'month-over-month enrollment growth' and the agent plans, derives the metric, and executes — even if that specific metric doesn't exist yet.

Expand

Growing Semantic Context

As your needs evolve, simply add new Cube models to expand the semantic layer. The LLM automatically gains access to richer metadata — new dimensions, measures, and joins — enabling increasingly sophisticated queries without any ML training or fine-tuning.

A Crew of Bounded Agents

One Supervisor. Four Specialists. Exactly One Engine Each.

Zynomi's agent fleet is designed so the supervisor owns no data tools — it classifies your question and routes it to a bounded specialist. Each specialist sees only its own engine's tools, everything is read-only by construction (one gate, tested in CI, not promised in a prompt), and tools compute while the model narrates.

Supervisor

Owns no data tools — classifies the question and routes it to bounded specialists

Trial Metrics Analyst

Governed KPIs only

Semantic Layer

Centrally defined metrics

Study Historian

Fixed-shape Cypher via MCP

Temporal Graph

Relationships + time

Operations Agent

Read-only lookups

Transactional Store

Current operational state

Data Steward

Quality & lineage checks

Quality / Lineage

Tests and lineage metadata

One engine per specialist

Each agent sees only its own context's tools

Read-only by construction

One gate, tested in CI — not promised in a prompt

Tools compute, the model narrates

Agents never re-derive a number, never invent an edge

Three classes of questions, one front door

Analytical

What was the enrollment rate across Phase III studies last quarter?

Routed to the Trial Metrics Analyst — computed from governed KPIs in the semantic layer.

Graph

Show everything that happened after Amendment 4 — who requested it, who approved it, which sites were affected.

Routed to the Study Historian — one traversal of the temporal knowledge graph.

Hybrid

Which sites affected by Amendment 4 saw more protocol deviations afterward?

The graph finds the affected sites, the analytical layer computes before/after deviation rates, and the LLM composes one explanation.

The Complete Agentic Stack

From Raw Data to Intelligent Insights

Zynomi CTMS ships a ready-to-use Modern Data Lakehouse with a governed Semantic Layer, supporting Bring Your Own Data Visualizations and an Agentic Analytics AI Chatbot whose answers are generated from governed metric definitions. The entire lakehouse-to-semantic pipeline is packaged using dbt Core and Cube Core, but can be swapped to their cloud versions (dbt Cloud, Cube Cloud) for high-scale enterprise deployments.

Agent Crew & Chat Interface

React Microfrontend

A custom-built React chat client embedded as a microfrontend plugin directly in the application. Behind it, a supervisor agent routes each question to bounded specialists — a seamless, branded experience within your clinical trial management workflow.

MCP Server Bridge

Node.js + Python

Model Context Protocol connecting AI to your data

🔗 ctms-mcp-server.zynomi.com

Semantic Layer

Cube.dev

Governed metrics, pre-joined views, consistent definitions

Temporal Knowledge Graph

Graphiti + FalkorDB

Clinical ontology + GraphRAG: entities and relationships with valid-from/valid-to on every edge — amendment provenance, affected sites, and before/after history in one traversal. In development as part of the Zynomi Agent Fabric (ZAF).

Data Lakehouse

dbt + PostgreSQL

Bronze/Silver/Gold medallion architecture with CDISC-compliant models. PostgreSQL is the default warehouse, with support for Snowflake, Databricks, and Redshift.

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Key Capabilities

Everything You Need for Intelligent Clinical Analytics

Pre-joined, business-friendly views that abstract the complexity of the underlying star schema. Consistent metric definitions across all tools — from AI chatbots to Tableau dashboards.

  • Pre-aggregated clinical KPIs
  • CDISC-aligned data models
  • Single source of truth for metrics

Semantic Layer

Pre-joined, business-friendly views that abstract the complexity of the underlying star schema. Consistent metric definitions across all tools — from AI chatbots to Tableau dashboards.

MCP Server

Model Context Protocol bridge connecting AI assistants to your clinical data. 6 built-in tools for querying, exploring, and analyzing trial data programmatically.

Grounded, Traceable AI

Answers are grounded twice: governed numbers come from the semantic layer, computed exactly as centrally defined; relationships and history come from the temporal knowledge graph (clinical ontology + GraphRAG). Tools compute, the model narrates — and every number is traceable back to source data.

Bring Your Own BI

Connect Tableau, Power BI, Metabase, or Looker to the semantic layer over its Postgres-compatible SQL API. Your analysts keep their favorite tools while benefiting from governed, consistent metrics.

Multi-Step Analysis

AI executes complex analytical workflows, not just single queries. Ask for derived metrics, comparisons across time periods, or cohort breakdowns — the agent plans and executes.

Extensible Semantic Models

Expand your analytical capabilities by adding new Cube models. The LLM automatically discovers new dimensions, measures, and relationships — delivering richer context without any ML training.

Data Lineage & Governance

From Source to Insight — Complete Transparency

Every metric, every dashboard, every AI response is traceable back to its source. Our medallion architecture (Bronze → Silver → Gold) ensures data quality at every step, while dbt provides complete lineage documentation.

DBT Data Lineage Diagram showing Bronze, Silver, and Gold layer transformations

Key Features

Complete data lineage from source to dashboard
Medallion architecture: Bronze (raw), Silver (cleaned), Gold (analytics-ready)
Automated data quality checks at each transformation
CDISC-compliant output models for regulatory submission

Medallion Architecture

Bronze — Raw ingested data
Silver — Cleaned & validated
Gold — Analytics-ready

Ready to Transform Your Clinical Analytics?

Experience AI that works from your governed clinical data definitions — answers grounded in the semantic layer and traceable to source.